Capturing the spatial and temporal dynamics of tumor stroma for on-chip optimization of microenvironmental targeting nanomedicine
Giorgia Imparato, Francesco Urciuolo, Claudia Mazio, Paolo A. Netti
Abstract
conditions. In this review, after a brief description of the origin of tumor microenvironment heterogeneity, some examples of nanomedicine approaches targeting the tumor microenvironment have been reported. Further, how advanced 3D bioengineered tumor models coupled with a microfluidic device can improve the design and testing of anti-cancer nanomedicine targeting the tumor microenvironment has been discussed. We highlight that the presence of a dynamic extracellular matrix, able to capture the spatiotemporal heterogeneity of tumor stroma, is an indispensable requisite for tumor-on-chip model and nanomedicine testing.
Topics & Concepts
Tumor microenvironmentStromaNanomedicineExtracellular matrixMetastasisCancer researchTumor progressionStromal cellCrosstalkCancer cellCancerBiologyMedicineNanotechnologyTumor cellsCell biologyImmunologyMaterials scienceInternal medicineEngineeringElectronic engineeringNanoparticleImmunohistochemistry3D Printing in Biomedical ResearchCancer Cells and MetastasisCellular Mechanics and Interactions