Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients
Carl A. Pierce, Paula Preston‐Hurlburt, Yile Dai, Clare Burn Aschner, Natalia Cheshenko, Benjamin Galen, S. Garforth, Natalia G. Herrera, Rohit K. Jangra, Nicholas C. Morano, Erika P. Orner, Sharlene Sy, Kartik Chandran, James Dziura, Steven C. Almo, Aaron M. Ring, Marla J. Keller, Kevan C. Herold, Betsy C. Herold
Abstract
T cells. Moreover, serum neutralizing antibody titers and antibody-dependent cellular phagocytosis were higher in adults compared to pediatric patients with COVID-19. The neutralizing antibody titer correlated positively with age and negatively with IL-17A and IFN-γ serum concentrations. There were no differences in anti-spike protein antibody titers to other human coronaviruses. Together, these findings demonstrate that the poor outcome in hospitalized adults with COVID-19 compared to children may not be attributable to a failure to generate adaptive immune responses.