Development of p-amino acetanilide functionalized multi-walled carbon nanotubes as an effective carrier for lansoprazole release
Milad Abniki, Zahra Azizi, Sepideh Poorebrahim, Elham Moniri
Abstract
Abstract Nowadays the nano-drug delivery system is an appropriate procedure for solving the problem of controlling drug performance in a traditional method. For this purpose, a new nano-adsorbent of modification multi-walled carbon nanotubes with cyanuric chloride and para-amino acetanilide was synthesized for the effective sorption and desorption of lansoprazole drugs. Physicochemical properties of the multi-walled carbon nanotubes with cyanuric chloride and para-amino acetanilide were then specified with energy dispersive spectroscopy, scanning electron microscope, infrared spectroscopy (IR), thermal gravimetric (TGA), and elemental analysis (CHN). The adsorption process followed by the drug release kinetics and isotherm models has indicated a good and acceptable kinetic adsorption and Langmuir isotherm model in conditions simulated. The maximum capacity value for the lansoprazole adsorption by nano-adsorbent was 48.781 mg g −1 at an optimal pH of 6. The result of the drug release mechanism was shown in the first 30 min in the stomach is as much as 30% of the drug is released into the environment by MT-CC/pA. The efficiency and adsorption capacity of the produced nano-adsorbent is extremely high for lansoprazole sorption.