RNA modifications and cancer
Phensinee Haruehanroengra, Ya Ying Zheng, Yubin Zhou, Yun Huang, Jia Sheng
Abstract
C, inosine and pseudouridine, in both coding and non-coding RNAs. In parallel, we present a few other cancer-related tRNA and rRNA modifications. We further discuss their roles in cancer promotion or tumour suppression. Understanding the molecular mechanisms underlying the biogenesis and turnover of these RNA modifications will be of great significance in the design and development of novel anticancer drugs.
Topics & Concepts
BiologyRNAComputational biologyGeneticsGeneRNA modifications and cancerCancer-related molecular mechanisms researchRNA Research and Splicing