Host cell cycle checkpoint as antiviral target for SARS-CoV-2 revealed by integrative transcriptome and proteome analyses
Liyan Sui, Letian Li, Yinghua Zhao, Yicheng Zhao, Pengfei Hao, Xuerui Guo, Wenfang Wang, Guoqing Wang, Chang Li, Quan Liu
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 pandemic, has posed severe threats to global public health, highlighting an urgent need to understand its pathogenesis and to develop antiviral therapies. Both DNA and RNA viruses can modulate cell cycle progression to maximize their replication. 1 However, the effects of SARS-CoV-2 on cell cycle progression remains largely unknown.
Topics & Concepts
TranscriptomeProteomeComputational biologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)BiologyCell cycle2019-20 coronavirus outbreakHost (biology)Cell biologyCellVirologyBioinformaticsMedicineGeneticsGeneGene expressionInfectious disease (medical specialty)PathologyOutbreakDiseaseinterferon and immune responsesVirus-based gene therapy researchAnimal Virus Infections Studies