Safety, tolerability, pharmacokinetics, and immunological activity of dual-combinations and triple-combinations of anti-HIV monoclonal antibodies PGT121, PGDM1400, 10-1074, and VRC07-523LS administered intravenously to HIV-uninfected adults: a phase 1 randomised trial
Magdalena E. Sobieszczyk, Sharon Mannheimer, Carmen A. Paez, Chenchen Yu, Theresa Gamble, Deborah Theodore, Wairimu Chege, Margaret Yacovone, Brett Hanscom, Jack Heptinstall, Kelly E. Seaton, Lily Zhang, Maurine D. Miner, Amanda Eaton, Joshua A. Weiner, Kenneth H. Mayer, Spyros A. Kalams, Kathryn E. Stephenson, Boris Jülg, Marina Caskey, Michel C. Nussenzweig, Lúcio Gama, Dan H. Barouch, Margaret E. Ackerman, Georgia D. Tomaras, Yunda Huang, David C. Montefiori
Topics & Concepts
PharmacokineticsMedicineTolerabilityAntibodyNeutralizationAdverse effectPopulationEpitopePharmacologyInternal medicineMonoclonal antibodyHuman immunodeficiency virus (HIV)Clinical trialImmunologyEnvironmental healthHIV Research and TreatmentHIV/AIDS drug development and treatmentHIV/AIDS Research and Interventions