A DNase Type VI Secretion System Effector Requires Its MIX Domain for Secretion
Chaya Mushka Fridman, Biswanath Jana, Rotem Ben‐Yaakov, Eran Bosis, Dor Salomon
Abstract
Specialized protein delivery systems are used during bacterial competition to deploy cocktails of toxins that target conserved cellular components. Although numerous toxins have been revealed, the activity of many remains unknown. In this study, we investigated such a toxin from the pathogen Vibrio parahaemolyticus. Our findings indicate that the toxin employs a DNase domain to intoxicate competitors. We also show that a domain used as a marker for secreted toxins is required for secretion of the toxin via a type VI secretion system.
Topics & Concepts
Type VI secretion systemSecretionEffectorBiologyNucleaseMicrobiologyBacteriaToxinVibrio choleraeCell biologyVirulenceBiochemistryGeneticsGeneVibrio bacteria research studiesAntibiotic Resistance in BacteriaYersinia bacterium, plague, ectoparasites research