Litcius/Paper detail

Selpercatinib and Pseudo-Decreases in Kidney Function

Hassan Izzedine, Élise Bouderlique, Benjamin Besse

2024New England Journal of Medicine14 citationsDOI

Abstract

Selpercatinib leads to pseudo-decreased kidney function, which impairs tubular creatinine excretion. Cystatin C has no tubular secretion and may be a better marker for managing selpercatinib treatment.

Topics & Concepts

Function (biology)Renal functionMedicineInternal medicineBiologyCell biologyRenal cell carcinoma treatmentPI3K/AKT/mTOR signaling in cancerCancer Mechanisms and Therapy