Age-dependent effects of a high-fat diet combined with dietary advanced glycation end products on cognitive function and protection with voluntary exercise
Lan Luo, Rui Li, Guiping Wang, Jingsi Chen, Liangkai Chen, Li‐Qiang Qin, Zengli Yu, Zhongxiao Wan
Abstract
Compared to HFD, HFD combined with an AGEs diet induced worse memory abilities only in middle-aged mice. Voluntary exercise effectively reversed the impaired cognitive performance from both age of mice, but differential mechanisms were observed.
Topics & Concepts
GlycationEndocrinologyInternal medicineTurnoverCognitive declineMedicineCognitionBiologyDiabetes mellitusDiseasePsychiatryManagementEconomicsDementiaNeuroinflammation and Neurodegeneration MechanismsAdvanced Glycation End Products researchNeurological Disease Mechanisms and Treatments