FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation
Jun Hu, Xing Liu, Shiyu Xia, Zhibin Zhang, Ying Zhang, Jingxia Zhao, Jianbin Ruan, Xuemei Luo, Xiwen Lou, Yang Bai, Junhong Wang, Louis Hollingsworth, Venkat Giri Magupalli, Li Zhao, Hongbo R. Luo, Justin Kim, Judy Lieberman, Hao Wu
Topics & Concepts
PyroptosisDisulfiramInflammationProgrammed cell deathCytokine stormInflammasomeApoptosisPharmacologyChemistryCaspaseProinflammatory cytokineMedicineImmunologyBiochemistryCoronavirus disease 2019 (COVID-19)DiseaseInfectious disease (medical specialty)PathologyInflammasome and immune disordersHeme Oxygenase-1 and Carbon MonoxideGout, Hyperuricemia, Uric Acid