Modulation of the Astrocyte-Neuron Lactate Shuttle System contributes to Neuroprotective action of Fibroblast Growth Factor 21
Yan Sun, Yue J. Wang, Suting Chen, Ying‐Jie Chen, Jie Shen, Wenbing Yao, Xiangdong Gao, Song Chen
Abstract
These results suggest that FGF21 alters metabolic parameters to mediate its neuroprotective functions. Modulation of the astrocyte-neuron lactate shuttle system can be one of the most efficient strategies for FGF21 in Alzheimer-like degeneration and contributes to improvements in brain metabolic defects and amyloid β-induced cytotoxicity. Our findings provide insights into the mechanisms underlying the effects of FGF21 on neurodegeneration and brain energy metabolism and suggest that FGF21 may have therapeutic value in the treatment of AD and other neurodegenerative diseases.
Topics & Concepts
AstrocyteNeuroprotectionNeuronModulation (music)NeuroscienceFibroblast growth factorFibroblastChemistryCell biologyBiologyPhysicsBiochemistryCentral nervous systemReceptorIn vitroAcousticsFibroblast Growth Factor ResearchKruppel-like factors researchEpigenetics and DNA Methylation