Discovery of 3-hydroxymethyl-azetidine derivatives as potent polymerase theta inhibitors
Yazhou Wang, Chao Wang, Jinxin Liu, Deheng Sun, Fanye Meng, Man Zhang, Alex Aliper, Feng Ren, Alex Zhavoronkov, Xiao Ding
Topics & Concepts
AzetidineHydroxymethylChemistryDNA polymeraseIsostereStereochemistryPolymeraseDrug discoveryDNACombinatorial chemistryBiochemistryCancer therapeutics and mechanismsAntibiotic Resistance in BacteriaDNA and Nucleic Acid Chemistry