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4-Octyl itaconate suppresses the osteogenic response in aortic valvular interstitial cells via the Nrf2 pathway and alleviates aortic stenosis in mice with direct wire injury

Xin Peng, Shuwen Su, Jingxin Zeng, Kaiji Xie, Xi Yang, Gaopeng Xian, Zezhou Xiao, Peng Zhu, Shaoyi Zheng, Dingli Xu, Qingchun Zeng

2022Free Radical Biology and Medicine29 citationsDOI

Topics & Concepts

Endoplasmic reticulumUnfolded protein responseOxidative stressHMOX1Cell biologyChemistryDownregulation and upregulationAortic valveInflammationReactive oxygen speciesMitochondrial ROSCancer researchInternal medicineMedicineBiochemistryBiologyEnzymeGeneHeme oxygenaseHemeCardiac Valve Diseases and TreatmentsAortic Disease and Treatment ApproachesGout, Hyperuricemia, Uric Acid
4-Octyl itaconate suppresses the osteogenic response in aortic valvular interstitial cells via the Nrf2 pathway and alleviates aortic stenosis in mice with direct wire injury | Litcius