Extracellular Loops of the Treponema pallidum FadL Orthologs TP0856 and TP0858 Elicit IgG Antibodies and IgG<sup>+</sup>-Specific B-Cells in the Rabbit Model of Experimental Syphilis
Kristina N. Delgado, Jairo M. Montezuma-Rusca, Isabel C. Orbe, Melissa J. Caimano, Carson J. La Vake, Amit Luthra, Christopher M. Hennelly, Fredrick N. Nindo, Jacob W. Meyer, Letitia D. Jones, Jonathan B. Parr, Juan C. Salazar, M. Anthony Moody, Justin D. Radolf, Kelly L. Hawley
Abstract
Recent identification and structural modeling of Treponema pallidum ’s ( Tp ) repertoire of outer membrane proteins (OMPs) represent a critical breakthrough in the decades long quest for a syphilis vaccine. However, little is known about the antigenic nature of these β-barrel-forming OMPs and, more specifically, their surface exposed regions, the extracellular loops (ECLs).
Topics & Concepts
TreponemaEpitopeAntibodyImmune systemBiologyAntigenMicrobiologyVirologyMonoclonal antibodyPeripheral blood mononuclear cellEpitope mappingImmunologySyphilisGeneticsHuman immunodeficiency virus (HIV)In vitroSyphilis Diagnosis and TreatmentVirology and Viral Diseasesvaccines and immunoinformatics approaches