Design, synthesis and biological evaluation of novel deoxyvasicinone-indole as multi-target agents for Alzheimer’s disease
Ashok Nerella, Madhukar Jeripothula
Topics & Concepts
ChemistryButyrylcholinesteraseAcetylcholinesteraseIndole testPharmacophoreAchéIC50Lead compoundStereochemistryDocking (animal)PharmacologyEnzymeCombinatorial chemistryBiochemistryIn vitroNursingMedicineCholinesterase and Neurodegenerative DiseasesComputational Drug Discovery MethodsSynthesis and biological activity