β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors
Lauren M. Slosky, Yushi Bai, Krisztián Tóth, Caroline Ray, Lauren K. Rochelle, Alexandra Badea, Rahul Chandrasekhar, Vladimir M. Pogorelov, Dennis Abraham, Namratha Atluri, Satyamaheshwar Peddibhotla, Michael P. Hedrick, Paul Hershberger, Patrick Maloney, Hong Yuan, Zibo Li, William C. Wetsel, Anthony B. Pinkerton, Lawrence S Barak, Marc G. Caron
Topics & Concepts
Allosteric modulatorAllosteric regulationFunctional selectivityG protein-coupled receptorBiologyArrestinAgonistG proteinPharmacologyReceptorSignal transductionCell biologyNeuroscienceBiochemistryReceptor Mechanisms and SignalingNeuropeptides and Animal PhysiologyPharmacological Effects and Assays