Guerbet-type β-alkylation of secondary alcohols catalyzed by chromium chloride and its corresponding NNN pincer complex
Himani Narjinari, Niharika Tanwar, Lakshay Kathuria, Raksh V. Jasra, Akshai Kumar
Abstract
β-Alkylation of alcohols has been efficiently accomplished using readily available 3d metal Cr under microwave conditions in air. Well-defined molecular Cr is involved with a KIE of 7.33 and insertion of α-alkylated ketone into Cr–H bond as the RDS.
Topics & Concepts
AlkylationPincer movementCatalysisChemistryChromiumKetoneChlorideMetalMedicinal chemistryOrganic chemistryAsymmetric Hydrogenation and CatalysisChemical Synthesis and AnalysisCarbon dioxide utilization in catalysis