Relationship between the n-3 index, serum metabolites and breast cancer risk
Jiaomei Li, Zhao-Hong Zheng, Min Liu, Yiping Ren, Yue Ruan, Duo Li
Abstract
) and 18β-glycyrrhetinic acid were significantly lower in breast cancer patients than those in healthy controls. In addition, serum 16α-hydroxy DHEA 3-sulfate was inversely correlated with the n-3 index (r = -0.412, p = 0.036). In conclusion, our findings suggest that the lack of n-3 PUFAs might be a potential risk factor for breast cancer, and the serum metabolite 16α-hydroxy DHEA 3-sulfate may play an important role in linking n-3 PUFA deficiency and breast disease etiology.
Topics & Concepts
Breast cancerDocosahexaenoic acidEicosapentaenoic acidInternal medicinePolyunsaturated fatty acidMetaboliteDehydroepiandrosterone sulfateEndocrinologyCancerArachidonic acidPhospholipidMedicineChemistryTaurineFatty acidBiochemistryHormoneAndrogenAmino acidEnzymeMembraneFatty Acid Research and HealthMetabolomics and Mass Spectrometry StudiesCancer, Lipids, and Metabolism