NIR‐II Responsive Hollow Magnetite Nanoclusters for Targeted Magnetic Resonance Imaging‐Guided Photothermal/Chemo‐Therapy and Chemodynamic Therapy
Xingyu Wang, Changwei Li, Junchao Qian, Xiaotong Lv, Hong Li, Jinglu Zou, Jiahui Zhang, Xiangfu Meng, Hongji Liu, Yong Qian, Wenchu Lin, Hui Wang
Abstract
Phototherapy in the second near-IR (1000-1700 nm, NIR-II) window has achieved much progress because of its high efficiency and relatively minor side effects. In this paper, a new NIR-II responsive hollow magnetite nanocluster (HMNC) for targeted and imaging-guided cancer therapy is reported. The HMNC not only provides a hollow cavity for drug loading but also serves as a contrast agent for tumor-targeted magnetic resonance imaging. The acid-induced dissolution of the HMNCs can trigger a pH-responsive drug release for chemotherapy and catalyze the hydroxyl radical (·OH) formation from the decomposition of hydrogen peroxide for chemodynamic therapy. Moreover, the HMNCs can adsorb and convert NIR-II light into local heat (photothermal conversion efficacy: 36.3%), which can accelerate drug release and enhance the synergistic effect of chemo-photothermal therapy. The HMNCs show great potential as a versatile nanoplatform for targeted imaging-guided trimodal cancer therapy.