Litcius/Paper detail

Palladium-catalyzed four-component cascade carbonylative cyclization to access carbonyl-bridged bisheterocycles

Yu‐Fei Song, Guangming Wei, Zhaolin Quan, Zhengkai Chen, Xiao‐Feng Wu

2023Organic Chemistry Frontiers13 citationsDOI

Abstract

We developed a palladium-catalyzed four-component carbonylative cyclization of alkenyl-tethered aryl iodides, trifluoroacetimidoyl chlorides and propargyl amines for the construction of carbonyl-bridged bisheterocycles.

Topics & Concepts

ChemistryPalladiumPropargylArylCatalysisCascadeComponent (thermodynamics)CarbonylationMedicinal chemistryCombinatorial chemistryOrganic chemistryCarbon monoxideAlkylThermodynamicsPhysicsChromatographyCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsCatalytic Alkyne Reactions