Two Polyketides Intertwined in Complex Regulation: Posttranscriptional CsrA-Mediated Control of Colibactin and Yersiniabactin Synthesis in Escherichia coli
Nadine Rehm, Alexander Wallenstein, Marla Keizers, Stefan Homburg, Giuseppe Magistro, Camille V. Chagneau, Hanna Klimek, Olga Revelles, Emmanuelle Helloin, Johannes Putze, Jean‐Philippe Nougayrède, Sören Schubert, Éric Oswald, Ulrich Dobrindt
Abstract
Secondary metabolite expression is a widespread strategy among bacteria to improve their fitness in habitats where they constantly compete for resources with other bacteria. The production of secondary metabolites is associated with a metabolic and energetic burden.
Topics & Concepts
BiologyGeneticsOperonVirulenceRegulation of gene expressionRegulatorGeneResponse regulatorEscherichia coliMutantBacterial Genetics and BiotechnologyEscherichia coli research studiesBacterial biofilms and quorum sensing