Oxidative stress-mediated PANoptosis and ferroptosis: Exploration of multimodal cell death triggered by an AIE-active nano-photosensitizer via photodynamic therapy
Yuqing Wang, Chuxing Chai, Wangxing Lin, Juanmei Cao, Zhe Li, Y. Jin, Yiting Xu, Jianyu Zhang, Yong Qu, Jinshan Zhan, Tianqi Zhao, Yufan Chen, Meng Gao, Changzheng Huang, Min Li
Abstract
Our findings reveal that AIE-driven PDT can orchestrate multimodal cell death in tumor through oxidative stress modulation. By concurrently activating PANoptosis and ferroptosis, this approach establishes a novel paradigm for overcoming limitations of conventional single-pathway targeted PDT.
Topics & Concepts
Photodynamic therapyPhotosensitizerOxidative stressProgrammed cell deathCancer researchChemistryNano-ApoptosisBiophysicsMedicineBiologyPhotochemistryMaterials scienceBiochemistryComposite materialOrganic chemistryAdvanced Nanomaterials in CatalysisFerroptosis and cancer prognosisExtracellular vesicles in disease