Folic Acid Antimetabolites (Antifolates): A Brief Review on Synthetic Strategies and Application Opportunities
Igor S. Коvalev, Grigory V. Zyryanov, Sougata Santra, Adinath Majee, Михаил В. Вараксин, Valery N. Charushin
Abstract
Antimetabolites of folic acid represent a large group of drugs and drug candidates, including those for cancer chemotherapy. In this current review, the most common methods and approaches are presented for the synthesis of therapeutically significant antimetabolites of folic acid, which are Methotrexate (MTX), Raltitrexed (Tomudex, ZD1694), Pralatrexate, Pemetrexed, TNP-351, and Lometrexol. In addition, the applications or uses of these folic acid antimetabolites are also discussed.
Topics & Concepts
RaltitrexedAntifolatePemetrexedMethotrexateFolic acidFolic Acid AntagonistsPharmacologyThymidylate synthaseAntimetaboliteMedicineChemotherapyInternal medicineFluorouracilCisplatinLung Cancer Treatments and MutationsSynthesis and biological activityClick Chemistry and Applications