Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity
Xiao Ma, Ping Zhu, Yonghe Ding, Hong Zhang, Qi Qiu, Alexey V. Dvornikov, Zheng Wang, Maengjo Kim, Yong Wang, Matthew R. Lowerison, Yue Yu, Nadine Norton, Joerg Herrmann, Stephen C. Ekker, Tzung K. Hsiai, Xueying Lin, Xiaolei Xu
Abstract
as the therapeutic target for AIC, and uncovers a previously unrecognized spatiotemporally-predominant mechanism that shall inform future translational efforts.
Topics & Concepts
CardiotoxicityAnthracyclineRetinoidMedicineAlpha (finance)PharmacologyRetinoid X receptor alphaInternal medicineCancer researchToxicityBiologyCancerBiochemistryBreast cancerRetinoic acidSurgeryConstruct validityPatient satisfactionGeneChemotherapy-induced cardiotoxicity and mitigationRetinoids in leukemia and cellular processesCancer Treatment and Pharmacology