The horse as a natural model to study reproductive aging-induced aneuploidy and weakened centromeric cohesion in oocytes
Marilena Rizzo, Nikola du Preez, Kaatje Ducheyne, C. Deelen, M. Beitsma, Tom A. E. Stout, Marta de Ruijter‐Villani
Abstract
matured oocytes from aged mares showed a higher incidence of aneuploidy and premature sister chromatid separation, and weakened centromeric cohesion. We therefore propose the mare as a valid model for studying effects of aging on centromeric cohesion; cohesion loss predisposes to disintegration of bivalents and premature separation of sister chromatids during the first meiotic division, leading to embryonic aneuploidy; this probably contributes to the reduced fertility and increased incidence of pregnancy loss observed in aged mares.
Topics & Concepts
AneuploidyCohesinBiologyEstablishment of sister chromatid cohesionSister chromatidsAndrologyPolar bodyMeiosisGeneticsChromosomeMedicineGeneChromosomal and Genetic VariationsGenetic Mapping and Diversity in Plants and AnimalsReproductive Biology and Fertility