Synchronous spiking associated with prefrontal high γ oscillations evokes a 5-Hz rhythmic modulation of spiking in locus coeruleus
Nelson K. Totah, Nikos K. Logothetis, Oxana Eschenko
Abstract
The prefrontal cortex (PFC) is thought to control activity in the noradrenergic locus coeruleus (LC). Prior anatomical and prefrontal stimulation studies demonstrated the potential for PFC-LC interactions; however, it is unknown what types of PFC activity affect the LC. Here, we show that transient increases in PFC high γ power and associated changes in PFC unit-pair synchrony are a potential sign of top-down control over the LC.
Topics & Concepts
Locus coeruleusNeuroscienceRhythmPrefrontal cortexPsychologyModulation (music)CommunicationPhysicsCognitionCentral nervous systemAcousticsNeural dynamics and brain functionPhotoreceptor and optogenetics researchNeuroscience and Neuropharmacology Research