Profiling Parkinson’s disease cognitive phenotypes via resting-state magnetoencephalography
Olivier Simon, Donald C. Rojas, Debashis Ghosh, Xinyi Yang, Sarah Rogers, C. Martin, Samantha K. Holden, Benzi M. Kluger, Isabelle Buard
Abstract
Can we better stage cognitive decline in patients with Parkinson's disease (PD)? Here, we provide evidence that mild cognitive impairment, rather than being simply a milder form of dementia, may be a qualitatively distinct phase in its development. We suggest that the most dramatic neurophysiological changes may occur during the time the PD brain transitions from normal cognition to MCI, then compensatory changes further occur as the brain "switches" to a dementia state.
Topics & Concepts
MagnetoencephalographyNeuroscienceCognitionResting state fMRIPsychologyPhenotypeProfiling (computer programming)DiseaseBiologyMedicineComputer scienceElectroencephalographyGeneticsPathologyGeneOperating systemFunctional Brain Connectivity StudiesNeural dynamics and brain functionNeurological disorders and treatments