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Design, synthesis, modeling studies and biological evaluation of pyrazole derivatives linked to oxime and nitrate moieties as nitric oxide donor selective COX-2 and aromatase inhibitors with dual anti-inflammatory and anti-neoplastic activities

Wael A. A. Fadaly, Yaseen A. M. M. Elshaier, Mohamed T. M. Nemr, Khaled R.A. Abdellatif

2023Bioorganic Chemistry46 citationsDOI

Topics & Concepts

ChemistryGrowth inhibitionPyrazolePharmacophoreCell growthApoptosisCell culturePharmacologyCancer researchStereochemistryBiochemistryMedicineBiologyGeneticsSynthesis and biological activityInflammatory mediators and NSAID effectsBioactive Compounds and Antitumor Agents
Design, synthesis, modeling studies and biological evaluation of pyrazole derivatives linked to oxime and nitrate moieties as nitric oxide donor selective COX-2 and aromatase inhibitors with dual anti-inflammatory and anti-neoplastic activities | Litcius