Hydride transfer-initiated synthesis of 3-functionalized quinolines by deconstruction of isoquinoline derivatives
Wenhui Mao, He Zhao, Min Zhang
Abstract
-isoquinolinium salts and 2-aminobenzaldehydes, proceeding with the merits of operational simplicity, high step and atom efficiency, good substrate and functional group compatibility, and mild conditions. The products are formed by reacting with the isoquinolyl motif as a two-carbon synthon along with the cleavage of its C3-N bond. Given the interesting applications of 3-aryl quinolines, the developed chemistry is anticipated to be further applied to develop new functional products.
Topics & Concepts
IsoquinolineSynthonChemistryArylHydrideQuinolineCombinatorial chemistryCatalysisBond cleavageFunctional groupOrganic chemistryMetalAlkylPolymerCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCatalytic Cross-Coupling Reactions