<i>Pseudomonas</i> Quinolone Signal-Induced Outer Membrane Vesicles Enhance Biofilm Dispersion in Pseudomonas aeruginosa
Adam C. Cooke, Catalina Florez, Elise B. Dunshee, Avery D. Lieber, Michelle L. Terry, Caitlin J. Light, Jeffrey W. Schertzer
Abstract
biofilm development and provide evidence that effective biofilm dispersion is dependent on the production of PQS-induced OMVs, which likely act as delivery vehicles for matrix-degrading enzymes. These findings lay the groundwork for understanding OMV contributions to biofilm development and suggest a model to explain the controlled matrix degradation that accompanies biofilm dispersion in many species.
Topics & Concepts
BiofilmPseudomonas aeruginosaMicrobiologyVirulenceQuinoloneAntimicrobialPseudomonasBiologyVesicleChemistryBacteriaMembraneAntibioticsGeneBiochemistryGeneticsBacterial biofilms and quorum sensingLegionella and Acanthamoeba researchBacterial Infections and Vaccines