NR4A1 destabilizes TNF mRNA in microglia and modulates stroke outcomes
Yao Yao
Abstract
Microglia play a dual role in stroke depending on their pro-inflammatory and anti-inflammatory polarization. A study in PLOS Biology identifies a new mechanism, through which the transcription factor NR4A1 negatively regulates TNF expression in microglia.
Topics & Concepts
MicrogliaBiologyTumor necrosis factor alphaCell biologyDual roleInflammationNeuroscienceMechanism (biology)Transcription factorMessenger RNAImmunologyGeneticsGeneChemistryEpistemologyCombinatorial chemistryPhilosophyNuclear Receptors and SignalingNeuroinflammation and Neurodegeneration MechanismsMacrophage Migration Inhibitory Factor