Herpes Simplex Oncolytic Viral Therapy for Malignant Glioma and Mechanisms of Delivery
Nicholas Erickson, Mihaela Stavarache, Ibrahim Tekedereli, Michael G. Kaplitt, James M. Markert
Abstract
The authors present a comprehensive review on the history and development of oncolytic herpes simplex viral therapies for malignant glioma with a focus on mechanisms of delivery in prior and ongoing clinical trials. This review highlights the advancements made with regard to delivering these therapies to a highly complex immunologic environment in the setting of the blood-brain and blood-tumor barrier in a safe and effective manner.
Topics & Concepts
Oncolytic virusMedicineGliomaHerpes simplex virusViral therapyClinical trialImmunologyPathologyVirusCancer researchCoronavirus disease 2019 (COVID-19)DiseaseInfectious disease (medical specialty)Virus-based gene therapy researchHerpesvirus Infections and TreatmentsCAR-T cell therapy research