Quinolizinium-based fluorescent probes for formaldehyde detection in aqueous solution, serum, and test strip <i>via</i> 2-aza-Cope rearrangement
Ajcharapan Tantipanjaporn, Karen Ka‐Yan Kung, Hoi‐Yi Sit, Man‐Kin Wong
Abstract
Formaldehyde is an abundant contaminant in food and environments causing various diseases. Thus, the development of fast, simple, and selective formaldehyde detection is of great interest. Herein, novel quinolizinium-based fluorescent probes were designed based on a 2-aza-Cope rearrangement reaction and showed high selectivity to formaldehyde by fluorescence emission shift. We successfully reduced the detection time by increasing the bulkiness of the homoallylic moiety. The probes were applied to detect formaldehyde in aqueous solution, serum, and paper format.
Topics & Concepts
FormaldehydeAqueous solutionFluorescenceChemistryCombinatorial chemistryPhotochemistryPhysical chemistryOrganic chemistryPhysicsOpticsMolecular Sensors and Ion DetectionAdvanced Chemical Sensor TechnologiesSynthesis and Biological Evaluation