The embryonic ontogeny of the gonadal somatic cells in mice and monkeys
Kotaro Sasaki, Akiko Oguchi, Keren Cheng, Yasuhiro Murakawa, Ikuhiro Okamoto, Hiroshi Ohta, Yukihiro Yabuta, Chizuru Iwatani, Hideaki Tsuchiya, Takuya Yamamoto, Yasunari Seita, Mitinori Saitou
Abstract
posterior intermediate mesoderm and appear to share origins anteriorly with the adrenal glands and posteriorly with the metanephric mesenchyme. Comparative single-cell transcriptomic analyses in mouse and cynomolgus monkey embryos reveal the convergence of the lineage trajectory and genetic programs accompanying the specification of biopotential gonadal progenitor cells. This process involves sustained expression of epithelial genes and upregulation of mesenchymal genes, thereby conferring an epithelial-mesenchymal hybrid state. Our study provides key resources for understanding early gonadogenesis in mice and primates.