Rhodium-catalyzed annulative approach to N–N axially chiral biaryls <i>via</i> C–H activation and dynamic kinetic transformation
Xiaohan Zhu, Hongli Wu, Yishou Wang, Genping Huang, Fen Wang, Xingwei Li
Abstract
NH and CH annulation through the dynamic kinetic transformation of the directing group and is highly enantioselective with good functional tolerance. Computational studies of a coupling system at the DFT level has been conducted, and the alkyne insertion was identified as the enantio-determining as well as the turnover-limiting step.
Topics & Concepts
RhodiumAxial symmetryCatalysisKinetic energyTransformation (genetics)ChemistryStereochemistryMedicinal chemistryPhysicsOrganic chemistryClassical mechanicsQuantum mechanicsBiochemistryGeneAxial and Atropisomeric Chirality SynthesisCatalytic C–H Functionalization MethodsAlkaloids: synthesis and pharmacology