Spontaneous membrane-less multi-compartmentalization <i>via</i> aqueous two-phase separation in complex coacervate micro-droplets
Nicolette G. Moreau, Nicolas Martin, Pierangelo Gobbo, T.‐Y. Dora Tang, Stephen Mann
Abstract
Polyelectrolyte/nucleotide multiphase complex coacervate droplets are produced by internalized aqueous two-phase separation and used for the spatially dependent chemical transfer of sugar molecules, providing a step towards the development of membrane-free "organelles" within coacervate-based protocells.
Topics & Concepts
CoacervateAqueous solutionChemistryPhase (matter)Chemical engineeringCompartmentalization (fire protection)MembraneAqueous two-phase systemChromatographyMembrane emulsificationMoleculeOrganic chemistryBiochemistryEnzymeEngineeringRNA Research and SplicingLipid metabolism and biosynthesisMicrobial Metabolic Engineering and Bioproduction