Low noncarbonic buffer power amplifies acute respiratory acid-base disorders in patients with sepsis: an in vitro study
Thomas Länger, Serena Brusatori, Eleonora Carlesso, Francesco Zadek, Paolo Brambilla, Chiara Ferraris Fusarini, František Duška, Pietro Caironi, Luciano Gattinoni, Mauro Fasano, Marta Lualdi, Tiziana Alberio, Alberto Zanella, Antonio Pesenti, Giacomo Grasselli
Abstract
Patients with sepsis are poorly protected against acute respiratory acid-base derangements due to a lower noncarbonic buffer power, which is caused both by a reduction in the major noncarbonic buffers, i.e. hemoglobin and albumin, and by a reduced buffering capacity of albumin. Electrolyte shifts from and to the red blood cells determining acute variations in strong ion difference are the major buffering mechanism during acute respiratory acid-base disorders.
Topics & Concepts
SepsisAlbuminRespiratory systemAcid–base homeostasisHemoglobinMedicineAcid–base imbalanceAcid–base reactionElectrolyteChemistryInternal medicineOrganic chemistryPhysical chemistryElectrodeRenal function and acid-base balanceSepsis Diagnosis and TreatmentHemodynamic Monitoring and Therapy