C5aR1 is a master regulator in Colorectal Tumorigenesis via Immune modulation
Peipei Ding, Ling Li, Luying Li, Xinyue Lv, Danlei Zhou, Qingkai Wang, Jianfeng Chen, Chaoqun Yang, Enjie Xu, Weixing Dai, Xin Zhang, Na Wang, Qi Wang, Wei Zhang, Long Zhang, Yuzhen Zhou, Hongyu Gu, Qun‐Ying Lei, Xuhui Zhou, Weiguo Hu
Abstract
Our study identifies C5a/C5aR1 signaling as a vital immunomodulatory program in CRC tumorigenesis and suggests a feasible preventive strategy.
Topics & Concepts
CarcinogenesisImmune systemCancer researchAzoxymethaneChemokineColorectal cancerImmunologyMyeloid-derived Suppressor CellBiologyMedicineCancerInternal medicineSuppressorComplement system in diseasesImmune Cell Function and InteractionImmune cells in cancer