Diagnostic Accuracy of a Noninvasive Test for Detection of Helicobacter pylori and Resistance to Clarithromycin in Stool by the Amplidiag H. pylori+ClariR Real-Time PCR Assay
Maxime Pichon, Benoit Pichard, Thierry Barrioz, Chloé Plouzeau, Vincent Croquet, Ginette Fotsing, Alexandre Chéron, E. Vuillemin, Marc Wangermez, Paul-Arthur Haineaux, Philippe Vasseur, Quentin Thiebault, Clémence Lefèvre, Anaïs de Singly, Julie Cremniter, Lauranne Broutin, Anthony Michaud, Christine Silvain, Christophe Burucoa
Abstract
The noninvasive detection of Helicobacter pylori and its resistance to clarithromycin could revolutionize the management of H. pylori -infected patients by tailoring eradication treatment without any need for endoscopy when histology is not necessary. Several real-time PCR tests performed on stools have been proposed, but their performances were either poor or they were tested on too few patients to be properly evaluated. We conducted a prospective, multicenter study including 1,200 adult patients who were addressed for gastroduodenal endoscopy with gastric biopsies and who were naive for eradication treatment in order to evaluate the performance of the Amplidiag H. pylori +ClariR assay recently developed by Mobidiag (Espoo, Finland).