<scp>DMAP‐Catalyzed</scp> C—N Bond Formation for Diverse Synthesis of Imidazo[1,2‐<i>a</i>]pyrimidine and Pyrimido[1,2‐<i>a</i>]benzimidazole Derivatives
Le‐Le Shang, Yunjiang Feng, Xing‐Lian Gao, Ziren Chen, Yu Xia, Weiwei Jin, Chenjiang Liu
Abstract
Summary of main observation and conclusion A DMAP (2‐dimethylaminopyridine)‐catalyzed condensation reactions for the successful direct construction of pyrimido[1,2‐ a ]benzimidazole or imidazo[1,2‐ a ]pyrimidine has been developed. The method utilizes readily available α‐bromocinnamaldehydes with 2‐aminobenzimidazole or 2‐aminoimidazole as starting materials in the presence of 2‐DMAP/TBHP. In the process, two C—N bonds were successfully constructed to synthesize target compounds. The current method features wide substrate scope, product diversification, and metal‐free conditions.
Topics & Concepts
ChemistryBenzimidazolePyrimidineCatalysisCombinatorial chemistrySubstrate (aquarium)CondensationMedicinal chemistryOrganic chemistryStereochemistryThermodynamicsGeologyPhysicsOceanographyCatalytic C–H Functionalization MethodsQuinazolinone synthesis and applicationsPhenothiazines and Benzothiazines Synthesis and Activities