Discovery and pharmacological characterization of a novel benzimidazole TRPV4 antagonist with cyanocyclobutyl moiety
Chongyi Ai, Zhuang Wang, Pengyun Li, Mengyuan Wang, Wenjuan Zhang, Huijuan Song, Xu Cai, Kai Lv, Xingjuan Chen, Zhibing Zheng
Topics & Concepts
ChemistryAntagonistIn vivoPharmacologyMoietyBenzimidazoleIC50In vitroPotencyStereochemistryCytotoxicityBiochemistryReceptorMedicineBiologyBiotechnologyOrganic chemistryIon Channels and ReceptorsRespiratory and Cough-Related ResearchIon channel regulation and function