Morphology-guided cellular behavior modulation with 3D-printed engineered ECM
Nian Liu, Yang Shi, Jingyuan Li, Kang‐Ning Shen, Zhaojie Zhang, Kai Liu, Jingyi Gu, Changyu Shao, Jue Shi, Zhijian Xie, Yuan Sun, Yong He
Abstract
In this study, we employed high-precision 3D printing to accurately reconstruct bio-scaffolds with varying morphologies that mimic the ECM, thereby eliminating the interference of complex biochemical signals. We systematically evaluated cellular responses to defined environmental features within heterogeneous ECMs, observing and summarizing novel phenomena, while further validating and elucidating the mechanisms by which the ECM regulates cell behavior. Ultimately, we demonstrated the potential applications of ECMs in regulating cell morphology and biological function.
Topics & Concepts
Modulation (music)Morphology (biology)Materials scienceNanotechnologyArtBiologyAestheticsGeneticsCellular Mechanics and Interactions3D Printing in Biomedical ResearchNeuroscience and Neural Engineering