Body temperature protein X-ray crystallography at 37 °C: a rhenium protein complex seeking a physiological condition structure
Frederick J. F. Jacobs, John R. Helliwell, Alice Brink
Abstract
The retention of the covalent binding of an organometalllic rhenium complex as a model for a technetium-99m imaging agent, to a protein at physiological body temperature 37 °C is described. Detailed structure comparisons are made to the related 100 K crystal structure. The generality of the need for this sort of analytical procedure for guiding ligand lead compound discovery is emphasised.
Topics & Concepts
RheniumCrystallographyCrystal structureX-rayChemistryCovalent bondX-ray crystallographyProtein structureBiochemistryInorganic chemistryOrganic chemistryDiffractionPhysicsOpticsQuantum mechanicsRNA and protein synthesis mechanismsProtein Structure and DynamicsEnzyme Structure and Function