Auxiliary‐Free Remote Dearomatizative Nitrenoid Transfer for Enantioselective Construction of Spirolactams
Bo‐Han Zhu, Wenting Guo, Qing Sun, Peng‐Cheng Qian, Long‐Wu Ye, Long Li
Abstract
Abstract An Ir‐catalyzed remote dearomatizative amidation for the enantioselective construction of chiral spirolactams in 70–93% yield with 81–96% ee was developed. This protocol represented a more atom‐economical approach to chiral spirolactams via Ir‐catalyzed nitrenoid transfer without the introduction of a traceless O‐silyl achiral auxiliary. magnified image
Topics & Concepts
Enantioselective synthesisChemistryYield (engineering)SilylationCatalysisCombinatorial chemistryOrganic chemistryStereochemistryThermodynamicsPhysicsCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis