Hypoxic Pretreatment of Adipose-Derived Stem Cells Accelerates Diabetic Wound Healing via circ-Gcap14 and HIF-1<i>α</i>/VEGF Mediated Angiopoiesis
Zhi Wang, Cheng Feng, Hao Liu, Tian Meng, Weiqing Huang, Xiao Long, Xiaojun Wang
Abstract
BACKGROUND AND OBJECTIVES: has an important protective function during wound healing. Here, we aim to clarify the regulatory mechanism of ADSCs. METHODS AND RESULTS: expression plays an important role in increased VEGF level. CONCLUSIONS: expression.
Topics & Concepts
Wound healingDownregulation and upregulationAdipose tissueTransplantationStem cellParacrine signallingVascular endothelial growth factorAngiogenesisCancer researchMedicineCell biologyAndrologyChemistryImmunologyBiologyVEGF receptorsInternal medicineReceptorGeneBiochemistryCircular RNAs in diseasesCancer-related molecular mechanisms researchMesenchymal stem cell research