Targeted degradation of VEGF with bispecific aptamer-based LYTACs ameliorates pathological retinal angiogenesis
Ping Zhou, Sai Zhang, Lin Li, Renshuai Zhang, Guizhi Guo, Yufei Zhang, Runa Wang, Miaoyuan Liu, Zhiyi Wang, Huijie Zhao, Guiwen Yang, Songbo Xie, Jie Ran
Abstract
Our findings present a novel strategy for targeting VEGF degradation with an aptamer-based LYTAC system, effectively ameliorating pathological retinal angiogenesis. These results suggest that VED-LYTACs have potential as therapeutic agents for managing NODs.
Topics & Concepts
AptamerAngiogenesisVEGF receptorsPathologicalRetinalRetinal DisorderDegradation (telecommunications)ChemistryCancer researchBiophysicsOphthalmologyMedicineMolecular biologyBiologyPathologyComputer scienceTelecommunicationsinterferon and immune responsesRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniques