Fusobacterium nucleatum promotes colon cancer progression by changing the mucosal microbiota and colon transcriptome in a mouse model
Na Wu, Yuqing Feng, Na Lyu, Di Wang, Wei‐Dong Yu, Yongfei Hu
Abstract
BACKGROUND: ) has long been known to cause opportunistic infections and has recently been implicated in colorectal cancer (CRC), which has attracted broad attention. However, the mechanism by which it is involved in CRC development is not fully understood. AIM: infection in an azoxymethane/dextran sulfate sodium salt (AOM/DSS) mouse model. METHODS: , the control, AOM/DSS-induced CRC and AOM/DSS-FUSO infection groups. RESULTS: which correlates with increased expression of oncogenic genes. CONCLUSION: in the oncogenic microbial environment of the colon.
Topics & Concepts
Fusobacterium nucleatumAzoxymethaneTranscriptomeColorectal cancerGut floraDysbiosisBiologyMicrobiomeCancer researchMicrobiologyImmunologyInternal medicineMedicineCancerGene expressionBioinformaticsBacteriaGeneGeneticsPorphyromonas gingivalisGut microbiota and healthHelicobacter pylori-related gastroenterology studiesImmune cells in cancer