Cultures in periprosthetic joint infections, the imperfect gold standard?
Marjan Wouthuyzen‐Bakker
Abstract
Culture-negative periprosthetic joint infections (PJI) are commonly described in the literature. By implementing a routine diagnostic workup and by optimizing tissue sampling and processing, the culture-negative rate can easily be reduced. When faced with a culture-negative PJI, several serological and molecular techniques are available that may aid in finding the causative microorganism. Clinical clues may guide the treating physician towards more atypical and rare microorganisms. A multidisciplinary team consisting of orthopaedic surgeons, microbiologists and infectious disease specialist are warranted in tailoring diagnostic testing and deciding on the surgical and antibiotic treatment approach.
Topics & Concepts
PeriprostheticJoint infectionsMedicineGold standard (test)Intensive care medicineInfectious disease (medical specialty)Multidisciplinary teamMultidisciplinary approachDiseaseSurgeryArthroplastyPathologyInternal medicineNursingSocial scienceSociologyOrthopedic Infections and TreatmentsOrthopaedic implants and arthroplastyInfectious Diseases and Tuberculosis