Parkin overexpression alleviates cardiac aging through facilitating K63-polyubiquitination of TBK1 to facilitate mitophagy
Beilei Gao, Wenjun Yu, Ping Lv, Xinyue Liang, Shiqun Sun, Yingmei Zhang
Topics & Concepts
ParkinMitophagyUbiquitinMitochondrionCell biologyAutophagyPINK1Ubiquitin ligaseBiologyChemistryApoptosisInternal medicineBiochemistryMedicineParkinson's diseaseDiseaseGeneAutophagy in Disease and TherapyMitochondrial Function and PathologyUbiquitin and proteasome pathways