Heterogenous Internalization of Nanoparticles at Ultra-Trace Concentration in Environmental Individual Unicellular Organisms Unveiled by Single-Cell Mass Cytometry
Qi Wu, Jianbo Shi, Xiaomeng Ji, Tian Xia, Li Zeng, Gengtan Li, Yuanyuan Wang, Jie Gao, Linlin Yao, Junjie Ma, Xiaolei Liu, Nian Liu, Ligang Hu, Bin He, Yong Liang, Guangbo Qu, Guibin Jiang
Abstract
cells could concentrate AuNPs, indicating a real environmental concern even when water was contaminated by only trace level of NPs. This method represents a promising tool for simultaneous determination of physiological status of cells together with the intracellular level of heavy metal or metallic NPs in study of biological effects.
Topics & Concepts
InternalizationMass cytometryFlow cytometryNanoparticleNanotechnologyTRACE (psycholinguistics)CytometryBiophysicsChemistryCell biologyCellMaterials scienceBiologyBiochemistryMolecular biologyPhenotypePhilosophyGeneLinguisticsNanoparticles: synthesis and applications3D Printing in Biomedical ResearchSingle-cell and spatial transcriptomics